If you open a store or make sales to individual consumers, you might need to collect sales tax. You need to apply for a tax ID # and file all apppropriate business permits required by your state.
if you are working with a wholesaler than you must have a tax id and business license. if you are selling on ebay or amazon than than you don t because they don t ask for it. Check this blog out ton s of info. on starting a business online similar to what your question is http://makemoneyonlineguaranteed100.blogspot.com/